Biocides are used in the treatment of damaging biological growth. However, not only do they kill pathogens, they also kill non-pathogens, meaning they may have undesirable side effects harming human health and/or the environment. For instance, in the service life phase, when released to the different environmental compartments (soil, surface waters, groundwater and air, depending on the actual use of the biocidal product), the active substances undergo a series of degradation reactions generating metabolites, transformation or reaction products that might significantly differ from the parent compounds in terms of their associated toxicity.
Considering the impact of active substances used in biocidal products and the metabolites, degradation and transformation products released to the environment during the application and service life phases, novel tools are necessary for the identification and substitution of biocides of ecotoxicological concern under an integrated life cycle perspective.
The use of non-animal alternative test methods has been foreseen in the Biocides Product Regulation, Regulation (EU) 258/2012 (BPR). The widespread use of non-testing methods (NTM) would help SMEs identifying, amongst other, the so called metabolites of ecotoxicological concern whereas facilitating the registering of biocidal active substances within the BPR and reducing animal testing.
The main target of the LIFE-COMBASE Project is to promote the sustainable use of biocidal active substances from a life cycle perspective. To this end, an on-line information system based on the combination of evidence based decision support systems (EBDSS) and proven computational toxicology modelling approaches will be implemented.

» The program of the second international workshop of the LIFE COMBASE Project is now available!

The second international workshop of the LIFE COMBASE Project will take place on the 17th October 2018 at the Istituto di Ricerche Farmacologiche Mario Negri (IRMFN) in Milano, Italy. During the workshop, which will be a one day event, the major outcomes of the project to date will be described. Furthermore, speakers representing different agencies -such as the German UBA- and research institutions in the area of knowledge of QSAR and non-testing methods have been invited to participate. The present workshop constitutes a networking event for stakeholders in the biocides value chain including industries, regulatory bodies and research institutions. Registration is free of charge, if interested please write an email to The programme can be accessed here.


The COMBASE LIFE Project and, more precisely, the work undertaken for the generation of an on line database with ecotoxicological information on biocidal active substances, has been presented in Rome in the frame of the SETAC Europe 28th Annual Meeting. The poster is co-authored by three beneficiaries of the Project (INIA, INKOA and Xenobiotics) and it has been INIA the beneficiary responsible of attending the event and presenting the results obtained. The SETAC conference represents a relevant exchange forum where environmental scientists, industrial and governmental representatives can present, debate and disseminate the most recent scientific knowledge contributing to the sustainable use of chemicals. A research article is currently under preparation complementing the work described within the present framework.

» New dissemination materials now available!

The first International Workshop of the COMBASE Project has been successfully conducted in Milan on the 19th October 2017. The workshop was introduced by María Blázquez (INKOA) and Emilio Benfenati (IRFMN). Dr Benfenati referred that a new era for in silico tools is now taking place and that models should ideally be used as a first screening step in all assessments. The status of development of some of the actions of the project was introduced by Francesca Aceti (ITENE)- Action A.3.- and Maria Luisa Fernandez Cruz (INIA) -Action B.1.- Additional speakers took part in the event and introduced a series of initiatives at European level in the area of computational toxicology. Fruitful exchanges took place during the workshop. In addition to the workshop, the first project newsletter has now been released. Stay tuned on COMBASE’s latest developments by subscribing to it.