Dissemination Materials

Present section compiles the dissemination material generated and classified in chronological order. The type of documentation accessible from this section includes press releases on printed and internet media, technical articles conference abstracts and posters.

DateEventLocationResponsible Beneficiary(ies)
Supplementary Information
2019/09/24 COMBASE Third International Workshop Madrid (Spain) INKOA, IRFMN, INIA, ITENE, ProtoQSAR

The third and final workshop of the Project has taken place in Madrid on the 24th September 2019. In the event, ECHA and JRC representatives, amongst other, have participated as speakers and a general overview of the results that have been obtained all throughout the project have been presented. Project’s contribution towards a more sustainable approach in the biocides value chain has also been introduced to the audience.

Presentations are available under the Publications section of the website (Workshops and presentations).
2019/06 Technical article publication NA IRFMN

The peer reviewed article: Khan, K., Khan, P.; Lavado, G.; Valsecchi, C.; Pasqualini, J.; Baderna, D.; Marzo, M.; Lombardo, A.; Roy, K. & Benfenati, E. (2019). QSAR modeling of Daphnia magna and fish toxicities of biocides using 2D descriptors. Chemosphere 229: 8-17, has now been published.

2019/06/26-28 XXIII Congreso Español de Toxicología y VII Iberoamericano Sevilla (Spain) INIA, INKOA

Poster presentation: Hernández-Moreno D, Alté L, Navas JM, Blázquez M, Fernández-Cruz ML “Estudio comparativo in vitro/in vivo para evaluar la toxicidad aguda de biocidas y/o sus metabolitos en peces”.

2019/06/18-19 Authorization of biocidal products and their application by SMEs Prague, (Czech Republic) ProtoQSAR

Oral presentation: Gozalbes, R. “Computational approaches for the assessment of biocidal active substances of ecotoxicological concern: the COMBASE experience”.

2019/05/29-30 SETAC Europe 29th Annual Meeting Helsinki (Finland) INKOA, INIA, XNB

Platform communication: Blázquez, M; Ranero, I; Andreu-Sánchez, O; Hernández-Moreno, D; Fernández-Cruz, ML. Addressing the knowledge gap in relation to ecotoxicological impacts of biocidal active substances and environmentally relevant metabolites.

2019/05/21-24 JRC Summer School on Non-Animal Approaches in Science Ispra (Italy) ProtoQSAR

Poster presentation: Gómez-Ganau, S. and Gozalbes, R. “A biocide-like QSAR model for the prediction of growth inhibition in the algae P. subcapitata”. 

2019/01/10 Press release NA INKOA, INIA, XNB
A reference to COMBASE and, particularly, to the article by Hernández-Moreno et al (2019), has been included in Higiene Ambiental.
2018/12/13 Technical article publication NA INKOA, INIA, XNB

The peer reviewed article: Hernández-Moreno, D., Blázquez, M., Andreu-Sánchez, O., Bermejo-Nogales, A., & Fernández-Cruz, M. L. (2019). Acute hazard of biocides for the aquatic environmental compartment from a life-cycle perspective. Science of The Total Environment. 658: 416-423 has now been published..

2018/10/24-25 BIOCIDES STAKEHOLDER’S DAY Helsinki (Finland) ITENE

ITENE has attended the biocides stakeholders’ day taking place on the 24th and 25th October 2018, in Helsinki. Three different sessions took place on the first day: session 1 – developments at EU level; session 2 – developments on biocidal products; session 3 – panel discussion. Topics focused on regulatory issues affecting companies in biocidal sector, including Brexit framework; as well as the new improvements ECHA have been developed in biocides (specific good practices, recommendations for a successful authorisation, or the new information available in the web). The second day consisted of a practical training session of the new developed version of IUCLID.

2018/10/17 COMBASE Second International Workshop Milan (Italy) INKOA, IRFMN, INIA, ITENE, ProtoQSAR 
The second international workshop of the COMBASE LIFE Project has been held on the 17th October 2018, at the IRFMN in Milan. Various stakeholders of industrial nature participated as speakers, namely CentroREACH in Milano and ENDURA, located in Bologna. The JANUS and toDIVINE Projects were both introduced by representatives of the German UBA. In the afternoon session the most recent outcomes of COMBASE were presented including the comparison of the in vivoin vitro and in silico data of fish toxicity for biocidal active substances and their corresponding metabolites by Maria Luisa Fernandez-Cruz from the INIA; newly developed models for algae and microorganisms and fish and Daphnia, by Sergi Gomez from ProtoQSAR and Anna Lombardo from the IRFMN, respectively. A demo of VEGA was presented by Alberto Manganaro (Kode) and, finally, the Project’s database compiling ecotoxicological effects and Mobile APP were introduced by María Blázquez from INKOA. Presentations are available under the Publications section of the website (Workshops and presentations).
2018/11 COMBASE Newsletter N2 NA ALL
The second project’s newsletter is now available! In the present edition, the main outcomes of the project from October 2016 to October 2018 have been introduced. Information corresponding to the chemicals to be tested in vivo and in vitro for the different trophic levels; a preliminary view of the Webtool and some data corresponding to the in silico approaches carried out have been provided. 
2018/09/27 Federchimica Workshop Milan (Italy) IRFMN
Oral presentation: Benfenati, E. "Exploiting data on chemical substances to model environmental and (eco) toxicological properties" 
2018/07/11-13 11th Iberian Congress and 8th Ibero-American Congress on Environmental Pollution and Toxicology (CICTA 2018) Madrid (Spain) INIA, ProtoQSAR, XNB
A total of four abstracts have been submitted and accepted for the present conference:
(i) Goya, E.; Tolosa, J.; de Julián, J.V.; Gozalbes, R. “Desarrollo de métodos computacionales para la evaluación de la ecotoxicidad de biocidas: el proyecto LIFE-COMBASE (by ProtoQSAR)” – Oral presentation.
(ii) Hernández-Moreno, D.; Alté, L.; Navas, J.M.; Fernández-Cruz, M.L. “Estudios in vitro-in vivo para determinar la toxicidad aguda de biocidas y/o sus metabolitos en peces” (by INIA) - Oral presentation.
(iii) Ruiz-Costa, N.; San José, A.; Andreu-Sánchez, O. “LIFE-COMBASE PROJECT: Ecotoxicity of biocides for WWTP microorganisms” (by XNB) – Poster presentation.
(iv) Ruiz-Costa, N.; San José, A.; Andreu-Sánchez, O. “LIFE-COMBASE PROJECT: Ecotoxicological characterization of biocides in freshwater organisms from two trophic levels” (by XNB) – Poster presentation.
The results of a number of implementation actions (namely B.1.) have been actively disseminated within the present event.
2018/06/11-15 18th International Conference on (Q)SAR in Environmental and Health Sciences Bled (Slovenia) IRMFN
Poster communication Como, F.; Capelli, C.; Marzo, M.; Toma, C.; Benfenati, E. QSAR Models for “Biocides”: The example of the prediction of Daphnia magna acute toxicity.
2018/05/23-24 Nanostruc 2018 (The 4th International Conference on Structural Nano Composites) Berlin (Germany) INKOA, INIA, IRMFN

An article describing the issues encountered for the application of QSAR models to generate information regarding the ecotoxicological profile of engineered nanomaterials has now been published. The complete reference is: Blázquez, M., Fernández-Cruz, M.L., Gajewicz, A., Puzyn, T. and Benfenati, E. (2019) On the uses of predictive toxicology to approve the use of engineered nanomaterials as biocidal active substances under the Biocidal Products Regulation. IOP Conference Series Materials Science and Engineering 499. 

2018/05/13-17 SETAC Europe 28th Annual Meeting Rome (Italy) INIA, INKOA, XNB
Poster communication
Hernández-Moreno D, Blázquez M, Andreu-Sánchez O, Bermejo-Nogales A, Fernández-Cruz ML, Hazard evaluation of biocides and its metabolites for the aquatic compartment.
2018/03 Press release NA PROTOQSAR
Publication of an article entitled “Herramientas computacionales para la evaluación de la ecotoxicidad de biocidas” in Plagas Urbanas (www.plagas-urbanas.com) with explicit reference to LIFE-COMBASE and introduction to the uses of computational toxicology for the prediction of environmental parameters associated to biocides.
2018/02 Expocida IBERICA 2018 Madrid (Spain) PROTOQSAR
Fair – Networking event. Participation.
2017/11 COMBASE Newsletter N1 NA ALL
The first project's newsletter is now available! On the present edition, introductory data of the Project have been included in addition to some data of the progress so far. Further, some of the research initiatives for the development of new biocidal active substances that have been identified within project's monitoring actions have been introduced. In terms of social impact, several articles exemplifying the effects on human health of pyrethroids are described. A complete report containing the outputs of the monitoring actions will be produced by the end of the project. The newsletter can be accessed on the next link
2017/10/19 COMBASE First International Workshop Milan (Italy) INKOA, IRFMN, INIA, ITENE 
ProtoQSAR – As attendant
The first international workshop of the COMBASE LIFE Project has been held on the 19th October 2017, at the IRFMN in Milan. A variety of speakers both associated beneficiaries of COMBASE and external entities were invited to participate including representatives of the regulatory agencies (EFSA) and other European initiatives dealing with computational chemistry (JANUS Project and Danish QSAR Database, amongst other). More than 50 people attended the workshop and the satisfaction level was rated good to very good for what refers to the venue, contents of presentations, registration and general value of the workshop in practical terms.
2017/09/26-27 Biocides Stakeholders Day Helsinki (Finland) INKOA
INKOA attended the biocides stakeholders day on the 26th September during which the planned regulatory updates concerning biocidal products and active substances were introduced by the ECHA. Special attention was drawn towards endocrine disruptors and in situ generated active substances. Uncertainties in relation with the possible consequences of the Brexit were also noted. Alternatively, different companies introduced their experience in practical terms in relation with certain aspects of the BPR (Union Authorisation, for instance). KEMI (Swedish Chemicals Agency) addressed the issue of treated articles. 
On the 27th a training session for the ICT Tools for biocidal products registration (IUCLID; for instance) was attended too. 
The attendance to the present event is considered to be an opportunity to foster the uptake of the project by the relevant institutions at EU level particularly by the ECHA.
2017/06/23 Company Interview NA ProtoQSAR
The project was mentioned amongst the portfolio of the company during an interview. Additional information can be found at: http://ceeivalencia.emprenemjunts.es/?op=8&n=14181
2017/06/29 AIMPLAS Technical conference Valencia ProtoQSAR
The project was introduced during an oral presentation.
2017/06/28-30 AETOX Congress Valencia ProtoQSAR, XNB
Introductory poster and presentation of the Project were presented.
2017/03/23 Press release NA INKOA
A reference to the project has been published in the Spanish electronic journal Higiene Ambiental. An introduction to the project and some of the most relevant actions to date are introduced in such new. The link to the new is provided next: http://www.higieneambiental.com/productos-biocidas-y-equipos/hacia-un-uso-sostenible-de-los-productos-biocidas-con-ayuda-de-la-toxicologia-computacional
2016/09/21 Workshop LIFE PROSIL Italy INKOA (Authors Blázquez, M.; Unzueta, I.). Invitation by courtesy of IRFMN Poster presentation “COMBASE: A NEW PROJECT FOR BIOCIDES”

List of Dissemination Actions