COMBASE

Los biocidas se utilizan en el tratamiento del crecimiento biológico perjudicial. Sin embargo, no sólo matan a los organismos patógenos, también matan a los no patógenos, lo que significa que pueden tener efectos secundarios indeseables, dañando la salud humana y / o el medio ambiente. Por ejemplo, en la fase de vida útil, cuando se liberan a los diferentes compartimentos medioambientales (suelo, aguas superficiales, aguas subterráneas y aire, dependiendo del uso del biocida), las sustancias activas experimentan una serie de reacciones de degradación que generan metabolitos, productos de transformación o reacción que podrían diferir significativamente de los compuestos progenitores en términos de su toxicidad asociada.
Considerando el impacto generado por las sustancias activas empleadas en productos biocidas así como el de los metabolitos, productos de degradación y transformación liberados al ambiente en las etapas de vida de aplicación y servicio, se requieren nuevas herramientas que permitan identificar y sustituir biocidas de relevancia ecotoxicológica desde una perspectiva de análisis de ciclo de vida.
El uso de métodos alternativos que no emplean animales ha sido previsto en el Reglamento (UE) 258/2012 (BPR – Biocidal Products Regulation) sobre productos biocidas. El uso generalizado de métodos no probatorios (NTM, Non Testing Methods) ayudaría a las PYME a identificar, entre otros, los llamados metabolitos de relevancia ecotoxicológica, facilitando al mismo tiempo el registro de sustancias biocidas en el marco de la BPR y la reducción de los ensayos con animales.
El objetivo principal del proyecto LIFE-COMBASE es promover el uso sostenible de las sustancias activas biocidas desde el punto de vista del ciclo de vida. Con este fin, se implementará un sistema de información en línea basado en la combinación de sistemas de apoyo a la toma de decisiones basados en evidencia (EBDSS) y modelos basados en toxicología computacional.

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NOTICIAS/EVENTOS
24/02/2020
» Completion of the LIFE-COMBASE Project

The LIFE-COMBASE Project has been completed on the 30th September, 2019. Within the framework of the project, computational models have been developed specifically for biocidal active substances that allow estimating the impact of this type of substances on freshwater organisms. The data available for the development of the models (information in publications and international databases) have been complemented with experimental assays, providing new information regarding biocidal active substances and their metabolites of environmental relevance. The developed models have been implemented in consolidated tools in the area of computational toxicology (such as VEGA or ToxRead) as well as in a tool specifically developed within the project conceived to speed up the decision making process for the selection of active substances biocides with less environmental impact (http://webtool.life-combase.com). In addition, the project has tried to bring non-testing methods to potential users, including the industrial and academic sector, having developed a series of online training materials as well as several seminars, workshops and meetings. The videos of the project are accessible from: ; and .

31/10/2019
» New dissemination materials now available

Different sections of the website have been updated. Under the “Publications” section, the updated list of speakers participating in the three project workshops that have been organized throughout the project and access to their corresponding presentations (if accessible) have been included, a new section to access the Layman’s report synthesizing the main outputs of the project and providing some insights on project’s impact form environmental, social and economic perspective has been created too. Additionally, a new section will soon be made available providing free access to project videos that describe both the LIFE COMBASE Webtool and the Mobile APP developed within the project.

30/10/2019
» Third international workshop of LIFE-COMBASE

The third and final workshop of the Project took place in Madrid on the 24th September 2019. In the event, ECHA and JRC representatives in addition to representatives of the Spanish Ministry of Health, Consumption and Social Welfare and the Spanish Ministry for Ecological Transition, participated as speakers introducing the use of computational based approaches in the approval of biocidal active substances and biocidal products from a regulatory perspective. Project beneficiaries presented a general overview of the results obtained all throughout the project. How LIFE-COMBASE contributes towards a more sustainable approach in the biocides value chain was also introduced to the audience. Presentations are now available under the Publications section of the website (Workshops and presentations).